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Supports: methylation, mood, fertility, DNA repair

TNF-, IL-1 and IL-6 are associated with activation of bone-resorbing processes, and IL-8 is reported to polymorphonuclear leukocyte activity.[5,34] More recently, Dias et al .,[99] first time revealed that significant redox disturbances exist in neutrophils of patients with periodontitis, which are associated with deregulation of anti-inflammatory transcription factor Nrf2 pathway resulting in neutrophil hyperactivity/hyper-reactivity

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doi:10.1074/jbc.M510764200

He didnt have systemic manifestations

These findings support the potential role of dietary components, like selenium and polyphenols, in CRC prevention strategies (59)