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Intracellular Hormone Receptors (Nuclear Receptors) The steroid/thyroid hormone receptor superfamily, which includes but is not limited to, the glucocorticoid (GR), vitamin D (VDR), retinoic acid (RAR) and thyroid hormone (TR) receptors, is a class of proteins that reside in the cytoplasm, or the nucleus, and bind their lipophilic hormone ligands in these locations since the hormones are capable of freely penetrating the hydrophobic plasma membrane

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