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Obese rats fed with a high-fat diet weighed more initially (588.7 14.1 g) than rats on a standard chow diet (497.8 15.1 g, p 0.05, n.s.)

Rimonabant is a cannabinoid receptor 1 antagonist that became available for long-term treatment of obesity in the United Kingdom and other countries beginning in 2006 [27]
