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1992;263(6, part 1):C1181C1189

Lipoic acid might be able to increase glutathione synthesis in aged rats by up-regulating the expression of -glutamylcysteine ligase (-GCL), the rate-limiting enzyme in glutathione synthesis (31), and by increasing cellular uptake of cysteine, an amino acid required for glutathione synthesis (32)

The K7M2 cells were maintained in DMEM, also supplemented with 10% FBS and 1% P/S

4.3.3 Cellular lipotoxicity and fatty acids One of the main initiators of macrophage foam cell development and atherosclerosis is the disturbance of regular lipid metabolism in macrophages

Duration of treatment varies based on condition severity and individual response

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