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This technology bridges the gap between traditional in vitro models (oversimplified) and in vivo trials (ethically and logistically challenging), offering high-throughput screening of microbiome interventions

Experimental studies have shown that dietary supplementation with ketone esters or low-percentage fat enrichment can restore locomotor rhythmicity, normalize expression of SIRT1 and core clock genes, and ameliorate neurodegeneration [53]

Exogenously applied gibberellin reinforced the endogenous gradient, rather than eliminating it, a behaviour that was best reproduced in silico by assuming differential plasma membrane permeability to gibberellin (Rizza et al., Reference Rizza, Tang, Stanley, Grossmann, Owen, Band and Jones2021)

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