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Schlesinger is with the Clinical Research Center of the Carolinas in Charleston, South Carolina

It works by binding to retinoic acid receptors in skin cells, directly activating genes that control cell differentiation, proliferation, and collagen production

In the Nrf2/ARE pathway, LBP significantly increases the activity of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px), scavenges excessive reactive oxygen species (ROS), stabilizes mitochondrial membrane potential (MMP), and reduces cytochrome C release (26, 27)

125,126 A critical additional element of similarity is represented by the excess production of pro-inflammatory and pro-atherogenic cytokines, for example, TNF-, IL-1 and IL-6, that synergistically build and maintain a pro-inflammatory microenvironment in blood vessels

To enhance the therapeutic potential of the ruthenium catalyst and tackle challenging hypoxic tumors, the metal complexes is covalently linked to the side chain of a polymer that contains a carbon fluorinated moiety capable of delivering oxygen to the tumor site

Helguera et al