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Moreover, the rupture of the blood vessel wall in hemorrhagic stroke results in the accumulation of hemoglobin and heme iron at the extracellular milieu and subsequent iron-induced LPO and ferroptosis, thereby furtherly exacerbating the stroke-induced brain injury
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Also, p62 recruited to the damaged mitochondria ubiquitinates Mcl-1, leading to its degradation and activation of apoptosis [305]

S.SaxenaS.et al (2022)

Pairing MOTS-c with structured exercise, creatine, and mitochondrial support compounds addresses mitochondrial health through complementary and reinforcing mechanisms
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