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Moreover, the clinical trials of PF06649751 (NCT02847650 and NCT02687542), GZ/SAR402671 (NCT02906020), CEP-1347 (NCT00040404), ABBV-0805 (NCT04127695), and BIIB054 (NCT03318523), spheramine (NCT00206687), and neuronal progenitor stem cell (NCT00927108) therapy were discontinued due to various reasons (Figure 5)

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These injections work to eliminate pain temporarily by paralyzing the piriformis muscle and stopping spasm in the muscle

To mitigate such artifacts, existing studies have employed dose-response experiments, comparative analyses with known pharmacological agents, and rigorously designed control experiments (e.g., exclusion of polyphenol-related artifacts) to delineate concentration ranges where quercetins effects are most likely target-specific

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