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However, in white adipose tissues (WAT), PARIS protein levels remain unchanged, and PGC-1 is increased when Parkin is absent, indicating that the Parkin-PARIS axis regulates PGC1 in a tissue-specific manner [225]
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Two complementary studies have recently demonstrated that the overexpression of FoxO1 enhances CD8 T cell stemness and boosts the fitness of CAR T cells through metabolic reprogramming toward respiration, thereby augmenting antitumor immunity in a TCF1-independent manner [48,49,50]
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Mevissen, T
Ldhb +/+ (KP) mice and KrasLSL-G12D/WT;p53flox/flox
