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Metabolic signaling by lactate in the brain

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In contrast, CHMP1A haploinsufficiency greatly exacerbated FA- or cisplatin-induced AKI by promoting ferroptosis through iron accumulation [177]

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As the first line antioxidant, the maintenance of a healthy homeostatic level of cellular glutathione (GSH) is critical in keeping the immune system running optimally

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Plumbagin alleviates temporomandibular joint osteoarthritis progression by inhibiting chondrocyte ferroptosis via the mapk signaling pathways

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Furthermore, CPN-9, a novel NRF2 activator, is neuroprotective against mutant SOD1 H46R motor deficits and disease progression in mice (Kanno et al., 2012)

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