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An interesting study addressing this issue showed that patients with major depression that included psychosis had more differentially expressed proteins associated with energy metabolism, whereas patients with depression without psychosis had changes in proteins associated with cell growth and maintenance, although 53.7% of the altered proteins overlapped ( That alterations in mitochondria bioenergetics pathways contributed to the pathophysiology of depression also raise the possibility of developing mitochondrial biomarkers that can illustrate a better therapeutic approach to the treatment of depression

J., Soluble Protein Oligomers in Neurodegeneration: Lessons from the Alzheimer's Amyloid Beta-Peptide, Nat

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2017;26(3):50922.e6

As a molecule naturally occurring in the human body declining with age rather than foreign to our biology it rarely produces adverse reactions at the concentrations used in cosmetic formulations