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Researchers should determine suitability based on the requirements of their individual study protocols
People with pernicious anemia or other medical conditions affecting B12 levels

Older adults are more likely to be on multiple medications, increasing the potential for interactions

doi: 10.1021/acs.jmedchem.7b00389

Clinical trials confirmed no effect on serum IGF-1 levels, no negative effect on carbohydrate metabolism, and no anti-AOD-9604 antibodies detected in any participants

Pancreatic Insufficiency: The pancreas helps with B12 absorption, and not enough of it can cause deficiency
