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Due to their stability, tissue specificity, and sensitivity to disturbance, they provide significant potential for non-invasive diagnostics, prognostics, and patient stratification [581]
By competitively binding to p53, FOXO4-DRI displaces endogenous FOXO4, causing p53 nuclear exclusion and translocation to mitochondria where it triggers the intrinsic apoptotic pathway through caspase-3/7 activation
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