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The 5xFAD mouse genotype is characterized by the onset of amyloid plaques at 3 to 4 months of age, which progress to substantial and densely concentrated lesions in the brain (Oakley et al., 2006)

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Additionally, rare deficiencies of glutathione cycle enzymes (gamma-glutamylcysteine ligase, glutathione synthetase, 5-oxoprolinase, and gamma-glutamyl transferase) have all been associated with neuropsychiatric and cognitive impairments, although detailed phenomenological characterization has not been reported (9, 61, 62)

[DOI] [PubMed] [Google Scholar] 76.Hao Q., Wang M., Sun N.X., Zhu C., Lin Y.M., Li C., Liu F., Zhu W.W

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