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#### Indications: **Primary Indications:** Treatment and prevention of Vitamin C deficiency (scurvy)

National Academies of Sciences, Engineering and Medicine

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Rather than interacting with receptors on the plasma membrane of their target cells, the gasotransmitters (soluble gases such as nitric oxide and carbon monoxide, as unconventional neurotransmitters) can cross the cell membrane and act directly on molecules inside the cell [36]

Most protocols last 48 weeks, followed by a rest period

Phase 1 clinical trials safety and tolerability: The first human studies focused on establishing safety and tolerability in healthy volunteers