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We have reported that inhibition of mitochondrial fat oxidation in muscle induces FGF21 specifically in skeletal muscle of Cpt1b m/ mice 24
There are no known reports of adverse vascular effects despite its influence on cerebral blood flow
[DOI] [PMC free article] [PubMed] [Google Scholar] 59.Barr RG, Bourbeau J, Camargo CA, Ram FS

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Both medications affect similar hormone pathways that control appetite, digestion, and blood sugar