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Direct modulation of the ERK pathway is not commonly measured using human trials of resveratrol or curcumin but indirect measures of inflammation or oxidative stress [122, 334]

In addition, experimental evidence confirmed that Nrf2 works against chemotherapy and radiotherapy (Wu et al

The expression of MDGI is crucial for glioma cells and is grade dependent in human brain tumor specimens [93, 120]

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This lipid radical reacts with molecular oxygen to form a lipid peroxyl radical (LOO), which can propagate the chain reaction by abstracting hydrogen atoms from neighboring lipids, leading to the generation of more lipid radicals and peroxyl radicals [9]

Interestingly, Nrf2 expression is significantly downregulated in peritoneal tissue-resident macrophages isolated from Immune-responsive gene 1 ( Irg1 ) shRNA-injected tumor-bearing mouse (79)