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14.5 Clinical Trial Results in HIV-1 Infected Pediatric Subjects Between the Ages of 6 to Less than 18 Years In Study 106, an open-label, single arm trial the efficacy, safety, and pharmacokinetics of GENVOYA in HIV-1 infected pediatric subjects were evaluated in treatment-nave adolescents between the ages of 12 to less than 18 years weighing at least 35 kg (N=50) and in virologically-suppressed children between the ages of 6 to less than 12 years weighing at least 25 kg (N=52)

Nevertheless, current research is limited by suboptimal experimental models, incomplete mechanistic integration, and insufficient high-quality clinical evidence

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Interaction of VPA with different drugs Acetaminophen, ertapenem, propoxyphene, cilastatin/imipenem, aspirin/caffeine, doripenem, meropenem, lamotrigine, sodium oxybate, sodium benzoate, vorinostat, and sodium phenylacetate, are the most common medication interactions