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Similar substrate preferences and catalytic efficiencies are observed for SARS-CoV-2 and SARS-CoV PL pro , suggesting that inhibitors of SARS-CoV PL pro are a good starting point for lead compound optimization against SARS-CoV-2

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Such investigations are instrumental in advancing the understanding of how structural features influence receptor binding, bioavailability, and in vivo efficacy in peptide-based drug discovery