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This depletion can affect cellular repair and regeneration

While the profound adverse effects of smoking on the respiratory and cardiovascular systems are extensively documented and widely acknowledged, its direct and indirect impact on liver health has historically received comparatively less attention from the medical community, particularly hepatologists

Abstract To test the hypothesis that physical disruption of an intervertebral disc disturbs cell-matrix binding, leading to cell clustering and increased expression of matrix degrading enzymes that contribute towards degenerative disc cell phenotype