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Uncertainty regarding appropriate preclinical models, particularly for chronic versus acute infections, further increases development risk and cost (Theocharopoulos et al., 2020), discouraging investment and slowing translation of ID-ADCs ( 10.7 The translational valley of death The convergence of scientific, manufacturing, and regulatory challenges culminates in a pronounced translational valley of death, especially for neglected tropical diseases

doi: 10.1007/s10549-020-05764-6 62 BengtssonYSandsvedenMManjerJ

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