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Moreover, it has been shown that GLO-1 contributes to the maintenance of an immunosuppressive microenvironment through MG-H1-mediated upregulation of the immune checkpoint programmed death ligand 1 (PD-L1), thereby promoting cancer progression (39)

However, in controlled therapeutic settings, ozone therapy has demonstrated calculated oxidative stress induction, which activates therapeutic benefits without resulting in acute or chronic toxicity [29]

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Ascorbic acid suppresses the 2,3,7,8-tetrachloridi benxo-p-dioxin (TCDD)-induced CYP1A1 expression in human HepG2 cells

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doi:10.1016/j.clinthera.2023.12.010