glutathione depletion dna hypomethylation and Stalwart Anticancer Activity of Metallotherapeutics Inducing Programmed Cell Death: Opening a New Window for Cancer Therapy Summary. Depletion of glutathione (GSH)

177179, doi:10.1024/0040-5930.64.3.177

Each patient was placed on a trial of the GSH precursor NAC, -lipoic acid, and 2 g doses of either oral or intravenous GSH

Eagle, H

doi: 10.1158/1541-7786.MCR-19-0264 306 MedeirosBAllanAL

[22] Regulation of sulfur assimilation is tightly controlled to ensure balanced production of sulfur-compounds like cysteine, methionine, and glutathione

Another potential candidate would be the use of oxygenation/oxidizing agents such as chlorine dioxide (ClO 2 ), a gas that is readily dissolved in water and derived from its prodrug sodium chlorite (NaClO 2 ) (Andrs et al., 2022), that has been examined for their ability to penetrate biofilms and to target pathogenic microbes (Behnke and Camper, 2012)