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The recommended doses of 5001,100 mg daily for 1224 weeks are advised based on the optimal balance between efficacy and safety

10.1016/0006-8993(77)90462-0 Brain Res

Important things to consider for the rate of administration include: Watching the patients vital signs Changing the rate based on how the patient reacts Not giving it too fast to prevent bad reactions Emergency Protocols for Severe Deficiency For severe Vitamin B12 deficiency with neurological symptoms or severe anemia, emergency steps are needed

Detailed reporting of methods will help inform comparability across studies, while study designs with within-subjects measurements across multiple timepoints can help explain some of the behavioral variance

Take the form that is already active

However, at concentrations of 16, 32 and 64 mM, GST activity was 41, 24 and 42% lower at 12 h compared to 24 h incubation