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Houston, M., & Hays, L

In conclusion, this review outlines that a possible future precision approach to cardiovascular prevention would integrate gut and oral microbiome profiling, LC-MS/MS TMAO quantification, and a selected panel of circulating miRNAs into care pathways, which could trigger individualized interventions (dietprobiotics/berberineperiodontal management) with longitudinal monitoringand would be enabled by assay standardization, multicenter RCTs to define actionable thresholds and identify responders, and EHR-integrated decision support that could drive guideline adoption

SummaryDisease Initiation and the Metabolic Approach It is becoming apparent that the pathogenesis of conditions like neurodegeneration, insulin resistance, endocrine imbalances, liver and kidney disease are linked to metabolic disorders and in particular to mitochondrial dysfunction

MODY12: Results from specific types of mutations in the gene (ABCC8) encoding the transporter protein, ATP-binding cassette transporter subfamily C member 8