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[DOI] [PubMed] [Google Scholar] 100.Pontes H, Duarte JA, Guedes de, Pinho P, Soares ME, Fernandes E, Dinis-Oliveira RJ, Sousa C, Silva R, Carmo H, Casal S, Remio F, Carvalho F, Bastos ML

Its power is derived from its precise, three-dimensional structure

Their synergistic effects are largely mediated by complex PK interactions, particularly HHI and HDI

In another study, spermidine was able to rescue behavioural deficits in the PD C

In contrast, the enzymatic antioxidants (SOD, CAT, and GPx) declined steadily from day 0 to day 30

These effects were observed across multiple organ systems and disease models, highlighting its broad therapeutic potential