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Nutritional studies have also demonstrated significant cognitive benefits and neuroprotective potential of (poly)phenols 11,12,13,14

Despite these advances, no specific drug targeting ferroptosis has been developed for treatment of IRI

The analysis complied with the PRISMA 2020 guidelines [30]

The treatment normalized neurotransmitter levels (norepinephrine, dopamine, serotonin), highlighting its potential in ameliorating AD-like symptoms (Daneshmand et al., 2016)

Phenylephrine is the classic prototype for this drug class and is frequently utilized when hypotension is accompanied by severe tachyarrhythmias

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