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doi: 10.1016/S2213-8587(20)30118-2 13 SantosTLovellJShiellKJohnsonMIbrahimJE

The body needs time to adapt to simultaneous GLP-1, GIP, and glucagon modulation

Potential cognitive benefits: Studies suggest it may have positive effects on cognitive function, including memory and learning

Based on the multiple effects of blocking TNF-, an earlier use in the therapy algorithm has been discussed in order to benefit from the positive effects of TNF- therapy at an earlier stage of disease

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What NOT to expect in the first 3 nights: Sedation (DSIP is not a sedative a drugged or groggy feeling is a signal to check the dose) Complete resolution of chronic insomnia (sleep architecture remodeling takes longer) Stress or cortisol changes (HPA axis modulation requires sustained dosing) Administration timing: Community protocols describe subcutaneous DSIP 30-60 minutes before the intended sleep time