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NNMT predominantly localizes in adipose tissue and liver (Pissios, 2017)

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When NNMT is active, it methylates nicotinamide (a form of vitamin B3), making it unavailable for conversion into NAD a crucial molecule for energy production and cellular repair

Experimental models show increased cyclic AMP levels in adipocytes, indicating activation of second messenger systems typically linked to -adrenergic signaling

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