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Higher levels of post-translationally modified p--Syn (p-S) were also detected in the CSF of PD patients than that of controls (Majbour et al., 2016b)

Vieira GLT, Lossie AC, Lay DC Jr, Radcliffe JS, Garner JP

Sawada, 2017

Subacute and chronic injuries predominantly feature demyelination of the nervous system and megaloblastic anemia, with up to 96% of patients experiencing neurological damage ( Spinal Cord Lesions: Symptoms include gait instability, sensory deficits, and motor weakness, often progressing to paraplegia in severe cases ( 6.4 Auxiliary examinations 6.4.1 Imaging characteristics MRI findings often reveal T2 hyperintensities in the posterior columns of the spinal cord and subcortical white matter ( 6.4.2 Laboratory and neurophysiological examinations Decreased Vit B12 levels and elevated Hcy and MMA are hallmark findings in NO-induced neuropathy ( 6.5 Diagnosis and differential diagnosis Based on clinical experience, the diagnostic criteria for neurological damage due to long-term NO inhalation include the following: A history of NO exposure, particularly frequent short-term inhalations

95,99 Activation of Y 2 leads to lower NPY release and higher -MSH release

Acta Diabetol