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Collectively, CRISPRCas9-established SNCA dosage series, precise corrections and knockouts in hPS cells provide versatile platforms to interrogate -syns roles in PD and to test targeted therapeutic options

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2007;44:83-113.[DOI] 57

These effects have included elevated levels of reactive oxygen species, increased production of inflammatory cytokines, alterations in cellular energy metabolism and redox regulation, and mitochondrial dysfunction
