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Optimized Metabolic State: Glutathione & Vitamin D Modern lifestyle changes, including insufficient exposure to sunlight (think Michigan in the winter!) and a sedentary lifestyle, have undoubtedly left deep marks on human health, as theyre considered one of the primary causes of diabetes and obesity, as well as vitamin D deficiency

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SAMe is the principal biological methyl donor and participates in three key metabolic pathways in the liver polyamine synthesis, transmethylation and transsulfuration (Lu and Mato, 2008)