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Cells were labeled with anti-STARD3 antibodies (green) ( A G ) and in magenta with: anti-LAMP1 antibodies ( A , B ) to label LE/Lys, anti-EEA1 antibodies ( C ) to label early endosomes, anti-GM130 antibodies ( D ) to label the Golgi apparatus, anti-calnexin antibodies ( E ) to label the ER or phospho-specific antibodies (pS 209 STARD3, F , G )

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Molecular and cellular mechanisms involved in Helicobacter pylori-induced inflammation and oxidative stress

Interleukin-6 The major source of interleukin-6 (IL-6) seen in IBD has been shown to be intestinal epithelial cells and lamina propria mononuclear cells.48 Recent studies indicate the involvement of IL-6 in intestinal TJ regulation.49 IL-6 increases paracellular permeability selectively to cations, but not to macromolecules, with an increase in pore-forming claudin-2 in intestinal epithelial cells, which requires the mitogen-activated protein kinase (MEK)/extracellular signal-regulated kinase (ERK) and PI3K/Akt signaling activations

Ling H, Pickard K, Ivan C, Isella C, Ikuo M, Mitter R, Spizzo R, Bullock MD, Braicu C, Pileczki V, Vincent K, Pichler M, Stiegelbauer V, Hoefler G, Almeida MI, Hsiao A, Zhang X, Primrose JN, Packham GK, Liu K, Bojja K, Gaf R, Xiao L, Rossi S, Song JH, Vannini I, Fanini F, Kopetz S , Zweidler-McKay P, Wang X, Ionescu C, Irimie A, Fabbri M, Lanza G, Hamilton SR, Berindan-Neagoe I, Medico E, Mirnezami AH, Calin GA, Nicoloso MS

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