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The downregulation of SOD and upregulation of genes like MPO and HIF1 support this oxidative stress-driven mechanism

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10.3389/fonc.2017.00306 394 ScaliseM.PochiniL.GalluccioM.ConsoleL.IndiveriC

Similarly, the upregulation of cytokines production in epithelial cells has been shown to be suppressed by sulforaphane, including in Caco-2 [135], human lung epithelial cells (BEAS-2B) [136,143,145], and primary mouse tracheal and human bronchial epithelial cells [139]

Gyanwali B, et al
Previous notion considers that PARPi exerts an anticancer function through the basic mechanism called synthetic lethality [46]
