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Oxidative stress occurs when theres an imbalance between the production of reactive oxygen species (ROS) and the bodys ability to neutralize them with antioxidants

Glutathione is a critical cofactor in the livers phase II detoxification pathway

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As with GPCR stimulation, PMNs lacking PI3K fail to produce ROS in response to IgG IC stimulation (Kulkani et al., 2011)
