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Levocarnitine (usually at a dose of 100200 mg/kg/day) is a standard treatment regimen

Funding This study was funded by National Key R&D Program of China [2022YFC2503801]

The method for calculating the relationship between these two measurement values is to use the following formula: IFCC-HbA 1c (mmol/mol) = [DCCT-HbA 1c (%) 2.15] 10.929

The total SF-36 scores, especially the physical component scores, PHES scores, and the rate-correct scores of the inhibition test were improved within the L-carnitine group after 24 weeks of treatment (Supplementary Table 3)

Therefore, ERGO may suppress the kynurenine pathway possibly via suppressing the CXCL9-induced activation of IDO

and inhibiting lipopolysaccharide-induced NF-B p65 translocation and mitogen-activated protein kinase phosphorylation in dendritic cells, thereby reducing inflammation [125, 228]