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Several gut peptides whose levels are altered in obesity, such as ghrelin and incretins, may be involved in bone metabolism [219][220][221]

This approach operationalizes where, when, how much at the bedside and provides a reproducible scaffold for trials

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This lack of therapeutic success does result in some patients seeking off-label therapies, supplements, and other treatments that lack high-quality levels of evidence but provide hope of altering disease trajectory

In: Bergmayer M.V., editor