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Gene comparisons of young and old tissues from mice, rats, and humans revealed that age-related gene expression changes most remarkably involve a strong induction of inflammation and immune response genes

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Increased fat synthesis based on enhanced glycolytic activity (pklr1, sterol regulatory element-binding protein-1 [SREBP1c], fas, and liver X receptor a [lxra]) in aged mice partly accounted for hepatic steatosis (increased leukocytic infiltration) and necrosis (increased plasma aspartate aminotransferase [AST] activity), compared with reduced srebp1c and fas mRNA levels in young mice

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Laboratory tests should always be interpreted in the light of the patients personal history and ongoing medication since Hcy levels can increase in renal failure, hypothyroidism and in some genetic metabolic conditions (Romagnolo et al