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The progression of cardiovascular diseases, such as myocardial infarction and HF, is driven by core pathological processes, including structural remodeling (e.g., hypertrophy and fibrosis) and metabolic reprogramming of cardiomyocytes toward a fetal-like state [97]

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Major differences emerged comparing the immunosuppressive effect of tacrolimus (0.1 mg/kg) to that of the monotherapeutic intervention with metformin (200 mg/dL) on the peri-conceptional homeostasis of the ovarian M1 and M2 macrophages

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For example, HCV induces inflammatory responses by activating IRE1, which interacts with TRAF2 to phosphorylate JNK, leading to activation of inflammation mediators
