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With an increase in oxidative stress, Nrf2 is released and translocates to the nucleus, where it binds and activates the ARE and upregulates several genes associated with glutathione synthesis and antioxidant defense (Figure 2) [45,48]

However, the rate of weight loss differs

RNA content of human lymphocyte subpopulations

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Realistic timelines matter: expect initial brightening within 4-8 weeks , with significant dark spot fading around 3-4 months as pigmented cells shed through multiple turnover cycles