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In this aspect, treatments using long-acting dopaminergic agents or a continuous dopaminergic effect in the striatum have been associated with less severe motor complications, given alone or in combination with L-dopa [9]

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Hodge BA, Wen Y, Riley LA, Zhang X, England JH, Harfmann BD et al (2015) The endogenous molecular clock orchestrates the temporal separation of substrate metabolism in skeletal muscle

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