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Hot-spot KIF5A mutations cause familial ALS

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A prospective observational study in over 4,000 participants of the Framingham Heart Study and the Framingham Offspring Study with or without preexisting cardiovascular disease found no statistically significant association between vitamin E supplement intake and cardiovascular or all-cause mortality after a 10-year follow-up period (124)

The risk of MDD was even higher in people who also had COMT slow (MET) alleles
For glycemic control in type 2 diabetes, treatment is typically continued indefinitely as long as it remains effective and well-tolerated, with periodic assessment of the ongoing need for therapy
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