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A mild adult and severe infantile/neonatal form of deficiency have been reported though more prevalent in adolescents and young adults

According to a study by Winther et al., higher concentrations of plasma TMAO were related to mortality, CVDs, and poor renal outcome in patients with type 1 diabetes (137)

This mechanism is particularly useful during exercise, especially steady-state cardio where fat becomes the primary energy source

iScience 26 , 107757 (2023)

A CARDIA investigation indicated that TMAO may not contribute significantly to advancing early atherosclerotic disease risk in healthy early-middle-aged adults (44)

Physiol.-Cell Physiol