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The methodology was as follows: Peer-reviewed clinical literature indexed in PubMed and PubMed Central was searched with terms including: microneedling , micro-infusion , percutaneous collagen induction therapy , transdermal drug delivery , AquaGold , plus each named active ingredient (GHK-Cu, Argireline, niacinamide, Centella asiatica, hyaluronic acid molecular weight, recombinant epidermal growth factor)

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Accessed 21 May 2019 Sushko I, Novotarskyi S, Krner R et al (2011) Online chemical modeling environment (OCHEM): web platform for data storage, model development and publishing of chemical information