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Because initiation of the 2 treatments required injections in different sites (gluteal vs deltoid), patients were administered a placebo injection at the alternate site with the day 1 and day 8 injections of AL or active control

A deficiency of CBS is caused by a mutation of the CBS gene, and results in homocystinuria, a rare inborn error of metabolism in which plasma and urinary homocysteine levels are elevated above normal ranges

However, S -adenosyl-methionine, which, in addition to promoting GSH synthesis, was shown to prevent alterations in membrane lipid composition including cholesterol/phospholipids increase (103, 117), normalizes mGSH levels in alcohol-fed rats by preventing alcohol-induced membrane-fluidity loss (24, 45)

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