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The NICE (2022) CKS suggests that measuring vitamin B12 levels is unhelpful because they will rise regardless of effectiveness
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NNMT (Nicotinamide N-Methyltransferase) Inhibition Potently and selectively binds to the nicotinamide binding site of NNMT, blocking the methylation of nicotinamide using SAM 4
doi: 10.1016/0168-3659(90)90015-L
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