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NAD+ Injections should be refrigerated at all times

In fact, the liver stores so much B12 that it can take years for a deficiency to develop (EFSA, 2015

Feb 2017;107(2):301-304

The mechanism cited most often in the preclinical literature is upregulation of vascular endothelial growth factor signaling (VEGFR2) alongside modulation of the nitric-oxide system

Rare side effects can include: Changes in blood pressure

PMID: 224 UmemuraMHondaAYamashitaMChidaTNoritakeHYamamotoKet al