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This enzyme is responsible for the transformation of methylmalonyl-CoA to succinyl-CoA, which in turn is part of the citrate cycle

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Panyutich, A

Two previous MRS studies reported decreased occipital GSH levels in unmedicated patients with MDD [22,23], and another observed an inverse association between occipital GSH and anhedonia severity, such that lower GSH levels were associated with higher anhedonia scores [24]

[DOI] [PubMed] [Google Scholar] 45.Bjelakovic G., Nikolova D., Simonetti R

Secondly, we have studied the complex with a decarboxylated glutathione conjugate that is known to dramatically decrease the activity of the enzyme