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This discrepancy may stem from the fact that disease progression in clinical patients is more severe than that in experimental models, rendering treatments less effective

Molecular and Cellular Biology, 14(12), 79968006
Williamson DH, Thornton PS (2011) Ketone Body Production and Metabolism in the Fetus and Neonate

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That could be why so many of us often feel like we're not at our best

Some details about the risk factors for calciphylaxis can be seen in the following infographic