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The antifolates
doi: 10.1016/j.jocn.2011.12.028 177 CohenMHShenYLKeeganPPazdurR

10.1210/jc.2019-00987 36 GonzalezF.KirwanJ

Calculated values are always given as mean standard deviation

Disruption of the balance between these elements triggers evasion of apoptosis and promotes cell survival, thus contributing to cancer initiation and progression [33]

This review will specifically focus on the involvement of IGF signaling in five key steps of breast tumor progression: epithelial-to-mesenchymal transition, local invasion, angiogenesis, secondary tumor formation, and chemoresistance